Goal
To treat and cure Ebola Virus Disease (EVD) using ozone therapy
Problem
High mortality of Ebola virus infection and lack of effective approved treatments
Concept Summary
The authors describe a protocol that delivers a mixture of oxygen/ozone gas intravenously (direct intravenous gas, DIV), rectally, and as ozonized water, supplemented with vitamin C and glutathione-supporting compounds. They claim that ozone's strong oxidizing power rapidly inactivates the Ebola virus by oxidizing essential sulfhydryl groups on viral glycoproteins, while also modulating the host immune response. In a case series of four Ebola-positive patients, symptoms resolved within 2-4 days and full recovery was achieved without complications.
Detailed Description
The treatment protocol (Rowen-Robins Method) uses an ozone generator to produce an O_2/O_3 mixture (~=98 % O_2, 2 % O_3) at concentrations up to 55 ug/cc for intravenous infusion (20-40 cc per session). Rectal administration employs 36 ug/cc ozone (150-350 cc). Ozonized water is prepared by bubbling ozone at ~70 ug/cc into water for 15 min (300-500 cc) and taken orally. Patients also receive oral vitamin C (4-8 g/day) and a glutathione-recycling supplement (ThiodoxA(R)). The authors report immediate clinical improvement in four patients (three laboratory-confirmed, one high-risk exposure) and no disease development in a prophylactically treated high-risk individual.
Principles
- Oxidation of viral sulfhydryl groups to disulfides
- Redox-mediated viral inactivation
- Immune modulation via antioxidant enzyme induction
- Improved blood rheology and oxygen delivery
Scientific Domains
Materials
- Ozone gas (O_3)
- Oxygen (O_2)
- Water
- Vitamin C
- Glutathione-supporting supplement (ThiodoxA(R))
- Buffered Vitamin C(R)
Mechanisms of Action
- Intravenous ozone gas oxidizes viral envelope proteins
- Rectal ozone delivers systemic oxidative stress
- Ozonized water provides oral oxidative agents
- Vitamin C and glutathione support antioxidant recycling
Energy Sources
Applications
- Treatment of Ebola virus disease
- Potential therapy for other viral infections
Claimed Performance
Four of four Ebola-positive patients recovered within 2-4 days after initiation of ozone therapy; a fifth high-risk individual remained asymptomatic.
Experimental Evidence
Case series of four patients reported in the African Journal of Infectious Diseases (2016) with documented symptom resolution and recovery.
Replication Status
No independent replication reported; results confined to the authors' case series.
Limitations
- Very small sample size (n = 4)
- No control or placebo group
- Lack of quantitative virological data
- Potential for ozone-related toxicity if mis-administered
Red Flags
- Claims of cure based on anecdotal case series
- Absence of peer-reviewed randomized controlled trials
- Potential conflict of interest (authors are developers of the method)
