{
    "title": "Stabilized DHAA (DeHydroAscorbic Acid)",
    "inventor_name": "Douglas KITT",
    "publication_year": null,
    "device_name": "ReCverin C (stabilized L-ascorbic acid serum)",
    "goal": "Provide a stable, high-concentration vitamin C formulation that retains antioxidant activity and improves skin absorption.",
    "problem_addressed": "Rapid degradation and instability of L-ascorbic acid in aqueous solutions, leading to loss of efficacy and limited skin penetration.",
    "concept_summary": "The invention is a water-free, glycerin-based solution containing 10 % L-ascorbic acid (stabilized DHAA) at pH 2.7. By eliminating water and using pure vegetable glycerin as a humectant, the serum remains clear, colorless and retains >95 % of its vitamin C content for at least one year at room temperature. The low pH enhances skin penetration, while the formulation is free of emulsifiers, preservatives, colorants and fragrances.",
    "detailed_description": null,
    "category": "Medical & Dental Technologies",
    "principles": [
        "Stabilization of ascorbic acid by removal of water",
        "Use of vegetable glycerin as a non-reactive humectant matrix",
        "Acidic pH (~=2.7) to improve dermal absorption"
    ],
    "scientific_domains": [
        "Chemistry",
        "Pharmacology",
        "Dermatology"
    ],
    "mechanisms_of_action": [
        "Antioxidant scavenging of free radicals",
        "Collagen synthesis stimulation",
        "Antimicrobial and antiviral activity when combined with copper/peroxide"
    ],
    "materials": [
        "L-ascorbic acid",
        "Vegetable glycerin"
    ],
    "energy_sources": [],
    "inputs": [
        "L-ascorbic acid",
        "Vegetable glycerin"
    ],
    "outputs": [
        "Stabilized vitamin C serum"
    ],
    "claimed_performance": "Retains >95 % of its stated L-ascorbic acid concentration for a year at typical room temperature; increases skin vitamin C levels beyond those achievable by oral supplementation; provides moisturizing, collagen-stimulating and antioxidant effects.",
    "experimental_evidence": "Stability testing showed >95 % retention after one year of storage at room temperature; user reports of improved skin texture and reduced gingivitis when used as a mouth rinse.",
    "replication_status": null,
    "keywords": [
        "Dehydroascorbic acid",
        "Vitamin C",
        "Stabilized serum",
        "Glycerin",
        "Skin care"
    ],
    "related_technologies": [
        "Cosmetic serums",
        "Antioxidant topical formulations"
    ],
    "controversy_level": "low",
    "confidence_score": 0.9,
    "practicability_score": 0.8,
    "fringe_score": 0.1,
    "evidence_strength": 0.5,
    "risk_score": 0.1,
    "trl_estimate": 7,
    "source_urls": [
        "https://en.wikipedia.org/wiki/Dehydroascorbic_acid",
        "http://www.recverin.com"
    ],
    "organizations": [
        "ReCverin LLC"
    ],
    "applications": [
        "Topical skin care (moisturizing, anti-aging)",
        "Dietary vitamin C supplement",
        "Antimicrobial mouth rinse"
    ],
    "limitations": [
        "Potential tingling or irritation on sensitive skin",
        "Stability depends on maintaining a water-free formulation",
        "Limited peer-reviewed clinical data on efficacy"
    ],
    "open_questions": [
        "Long-term clinical benefits for skin health and antiviral activity",
        "Exact mechanism of enhanced skin penetration at low pH",
        "Effectiveness compared with other stabilized vitamin C delivery systems"
    ],
    "red_flags": [
        "Claims of superior absorption and antimicrobial effects are not supported by independent, peer-reviewed studies"
    ],
    "evidence_quotes": [
        "It will easily retain greater than 95 % of its stated L-ascorbic acid concentration for a year when stored at typical room temperatures, and it will remain crystal clear and colorless.",
        "The pH of an L-ascorbic acid serum has been shown to be a critical factor; absorption is much improved in serums with pH values of 3.0 or lower. ReCverin Cacent is formulated at pH 2.7 for best absorption.",
        "ReCverin C is extremely stable. It will easily retain greater than 95 % of its stated L-ascorbic acid concentration for a year when stored at typical room temperatures."
    ]
}